Nature Genetics 42, 737 (2010). doi:10.1038/ng0910-737

Nature Genetics 42, 734 (2010). doi:10.1038/ng0910-734

Authors: Ross C Hardison

What is the best way to identify regulatory DNA sequences such as enhancers, promoters, insulators and silencers? A new study shows that specific binding by a coactivator protein identifies enhancers that are invisible to common detection methods based on evolutionary constraint.

Nature Genetics 42, 733 (2010). doi:10.1038/ng0910-733

Authors: James J Bieker

The transition from fetal to adult β-like globin expression is a key step in the maturation of the red blood cell lineage. Two new studies show that the KLF1 zinc finger protein uses direct and indirect means to regulate the final switch from fetal to adult globin expression and that monoallelic loss of KLF1 expression leads to persistence of fetal hemoglobin.

Nature Genetics 42, 731 (2010). doi:10.1038/ng0910-731

Authors: Paul I W de Bakker & Amalio Telenti

Two genome-wide association studies for meningococcal disease and tuberculosis identify new loci associated with susceptibility to these infectious diseases. They highlight a role for the acquired and innate immune systems in host control of several human pathogens and demonstrate that denser genotyping platforms and population-specific reference panels are necessary for genetic studies in African populations.

Nature Genetics 42, 729 (2010). doi:10.1038/ng0910-729

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